A Study of relationship of serum lactate dehydrogenase levels with maternal and perinatal outcome in preeclampsia eclampsia

Preeclampsia is one of the commonest and most dreaded compilcations of pregnancy. It is third most common cause of maternal mortality. LDH is an intracellular cytoplasmic enzyme and levels of LDH increase in preeclampsia due to cellular death and hemolysis. So, it is a useful biochemical marker to evaluate severity of preeclampsia . The analysis of LDH may enrich the ability to predict and prevent preeclampsia in near future. This can further help in making decision regarding the management strategies to improve maternal and fetal outcome in preeclampsia.

Aims and objectives : To measure serum LDH levels in patients of preeclampsia and to establish a relationship of serum LDH with fetomaternal outcome and severity of disease.

A prospective study will be conducted in GGS medical college and hospital , faridkot on 90 preeclamptic and eclamptic antenatal women with gestational age 28 weeks onwards with singleton pregnancy who will be admitted and delivered in our institute.

Detailed history of patients, symptoms and complications of preeclampsia will be analyzed. Serum LDH levels will be estimated. All maternal complications, fetal outcome, gestational age at birth, APGAR score, birth weight and requirement of NICU admission will be analysed.