MRI to Characterize and Predict CF Liver Disease in PUSH Cohort

Completed

• Conditions: Pancreatic Insufficiency; Cystic Fibrosis Liver Disease

• Registration Number: NCT02979340
• Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Brief Summary

Specific Aim 1. Determine if valid results of non-sedated MRI based assessments of liver stiffness and lipid content can be obtained in more than 90% of children and young adults with cystic fibrosis.

Specific Aim 2. Determine hepatic lipid content using the HepaFat sequence and liver stiffness using MRE. Investigators will compare the results obtained by MRI with PUSH study grayscale ultrasounds in CF patients with normal, heterogeneous, homogeneous or nodular (cirrhotic) pattern on ultrasound.

Specific Aim 3. Creation of an imaging core lab to centralize evaluation of MR imaging data, allow for remote image upload, electronic data storage, and remote image viewing/interpretation. This infrastructure will be utilized to standardize image post processing.

Specific Aim 4. Using the longitudinal PUSH study, determine if MRI based imaging improves discrimination of subjects at risk for progression to advanced CF liver disease (development of cirrhosis) compared to using US imaging alone

Detailed Description

This proposal will be a cross sectional study of the current well-characterized PUSH cohort. Patients will receive an MRI at the time of their scheduled PUSH ultrasound. Ideally, the MRI will be performed the same day or a similar time point near liver ultrasound (+/-90 days, but Investigators will allow a larger window due to the slow progression of fibrosis).

Blinded radiology review of imaging sequences will be performed by a local study radiologist with central review performed by the Imaging Core. Analysis by the Imaging Core will include calculation of the liver stiffness, liver and spleen volume, and hepatic and lipid content for all MRI studies.

Study Timeline

• Study First Submitted: 2016-11-18
• Study First Submitted QC: 2016-11-28
• Study First Posted: 2016-12-01
• Study Start: 2017-01-27
• Primary Completion: 2019-12-27
• Study Completion: 2019-12-27
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-08
• Last Update Posted: 2025-04-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

1. Currently enrolled in longitudinal follow up in PUSH study at a site with MR elastography.

Exclusion Criteria

1. Age under 6 years (all current patients at time of opening of this study will be greater than 6 years of age).
2. Internal appliance or hardware that is not compatible with MR.
3. Inability to obtain MRI within 6 months of US.
4. Inability to cooperate with MRI.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change over Time in Liver stiffness and Lipid content over time using MRE	BSL, Year 1, Year 2	Analysis of variance (ANOVA) will be used to compare the distribution of liver stiffness (in kPa) and lipid content measures between all groups defined by PUSH study grayscale ultrasounds results over time.

Trial Locations

Locations (8)

Texas Children's Hospital; 🇺🇸 Houston, Texas, United States

Riley Hospital for Children; 🇺🇸 Indianapolis, Indiana, United States

Seattle Children's Hospital; 🇺🇸 Seattle, Washington, United States

Cincinnati Children's Hospital Medical; 🇺🇸 Cincinnati, Ohio, United States

Children's Healthcare of Atlanta; 🇺🇸 Atlanta, Georgia, United States

Children's Hospital Colorado; 🇺🇸 Aurora, Colorado, United States

Johns Hopkins School of Medicine; 🇺🇸 Baltimore, Maryland, United States

Washington University School of Medicine; 🇺🇸 Saint Louis, Missouri, United States