跳至主要内容
临床试验/CTRI/2024/03/063513
CTRI/2024/03/063513尚未招募不适用

“Comparison of central corneal thickness in normal tension glaucoma and primary open angle glaucoma: A cross-sectional study”

Dr Harshita Dubey1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2024年3月15日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
60
试验地点
1
主要终点
central corneal thickness by pachymeter

研究概览

简要总结

It is by far one of the most significant factors contributing to irreversible bilateral blindness.¹

There have been efforts to develop screening techniques for the early diagnosis of the condition since early detection and treatment may reduce the incidence of visual field loss and subsequent blindness.²

If glaucomatous optic disc degeneration and field loss are to be prevented, patients must be properly screened, referred, counselled, and treated². The differences in central corneal thickness have an impact on the precision of intraocular pressure measurement using Non-contact tonometry. The current study compares the central corneal thickness of people with open angle glaucoma, those with normal tension glaucoma.

Normal-tension glaucoma is a characteristic glaucomatous optic neuropathy with intraocular pressures in the normal range.³ Primary open angle glaucoma (POAG) is a subset of the glaucomas defined by an open, normal appearing anterior chamber angle and raised intraocular pressure (IOP), with no other underlying disease.⁴

Measurement of central corneal thickness is one of the most crucial factor in the evaluation of any suspected glaucoma patient. is measured using ultrasonic pachymeter which is based on traditional A-scan ultrasonography⁵. Normal is 540microns (with a standard deviation of +1 or -1).⁶

A perimetry, often known as a visual field test, evaluates every aspect of vision, including the peripheral vision. Loss of peripheral vision is an early indicator of glaucoma.

Optical coherence tomography (OCT) is a non-invasive, non-contact imaging technique that uses infrared light to obtain high-resolution cross-sectional images of the fundus.⁷

This study aims to evaluate the comparison of central corneal thickness in NTG and POAG. This study is being undertaken to fill up the research void related to the comparison of CCT in glaucoma with the help of various modalities.

研究设计

研究类型
Observational

入排标准

年龄范围
35.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • Patients who have given informed consent.
  • Patients with Schaffer’s grading 3 to 4 on gonioscopy Patients who are a case of NTG with IOP<21 mmHg and glaucomatous disc changes .
  • POAG patients with untreated IOP of >21mmHg with glaucomatous disc changes.

排除标准

  • Patients who are not giving consent.
  • Patients with Schaffer’s grading ≤2 on gonioscopy.
  • Patients who have corneal pathologies.
  • Patients of corneal edema due to causes other than glaucoma.
  • Patients who have undergone previous intraocular surgeries.
  • Patients diagnosed with secondary glaucoma.
  • Chronic contact lens wearers.
  • Patients who have undergone any ocular laser therapy.
  • Diabetes mellitus.

结局指标

主要结局

central corneal thickness by pachymeter

时间窗: baseline

次要结局

  • central corneal thickness by pachymeter(baseline)

研究者

发起方
Dr Harshita Dubey
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Dr Harshita Dubey

Rohilkhand Medical college and hospital

研究点 (1)

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