ltrasound and magnetic resonance imaging to assess muscle contractile performance in FSHD.

Recruiting

• Conditions: disease of Landouzy-Dejerine; facioscapulohumeral dystrophy; 10028396; 10028302

• Registration Number: NL-OMON56047
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

All participants:
• Age between 18 and 70 years.
• Informed consent is given by the participant.
• Ability to read and understand written and spoken instruction in Dutch.
• Willingness and ability to understand nature and content of the study.

Patients with FSHD:
• Clinically and genetically proven FSHD type 1 or type 2.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:
All participants:
• BMI >= 35
• Other diseases that could diffusely affect muscle integrity or disturb the
imaging appearance beyond that what can be extrapolated.
• Wheelchair dependence.
• Pregnancy

In stage 2: participants who will undergo an MRI-scan
-Any contra-indications for MRI, including:
o Claustrophobia
o Pacemakers and defibrillators
o Nerve stimulators
o Intracranial clips
o Intraorbital or intraocular metallic fragments
o Cochlear implants
o Ferromagnetic implants (e.g. thoracic implant for scoliosis)
o Inability to lie supine for 60 minutes
o Necessity of (continuous) daytime ventilation
o Scoliosis surgery

Healthy participants:
• Any known nerve or muscle disorder affecting the muscles measured.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified