Circulating Anti-mullerian Hormone as Predictor of Ovarian Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 主要终点
- AMH in prediction of Ovulation in women with PCOS.
研究概览
简要总结
Polycystic ovary syndrome (PCOS) is found in 5% to 6% of women of reproductive age. It affects women's reproductive capability; thus patients have risks of infertility, miscarriage, and complicated pregnancy. A study revealed that the prevalence of oligoovulation or anovulation in patients with PCOS ranged from 65% to 80%. Anti-Mullerian Hormone (AMH) is an important regulator in the ovary that play a rule during development and function. It is suspected to affect clomiphene citrate (cc) resistance. In this study the investigator will assess the accuracy of AMH prediction of response to cc in women with PCOS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women diagnosed with PCOS
- •Women 20-35 years old.
- •BMI ≤30 kg/m without previous ovulation induction.
- •Partners with normal semen parameters Parameter World Health Organization (WHO) 2010 Volume1.5 ml Concentration 15 million/ml Progressive motility 32% Normal forms 4%
排除标准
- •Women with evidence of hyper-or hypothyroidism, hyperprolactinemia, Cushing's syndrome, congenital adrenal hyperplasia or androgen-secreting tumors.
- •Women with factors of infertility other than PCOS
- •Women with incomplete data.
研究组 & 干预措施
Group A: CC & ovulation
AMH level is measured before Clomiphene citrate 100 mg daily for 5 days & detecting Follicular growth assessment by TVU will be performed at day 12 of the menstrual period. Successful and unsuccessful follicular growth will be compared according to the subjects' respective AMH levels.
干预措施: Clomiphene Citrate (Drug)
Group A: CC & ovulation
AMH level is measured before Clomiphene citrate 100 mg daily for 5 days & detecting Follicular growth assessment by TVU will be performed at day 12 of the menstrual period. Successful and unsuccessful follicular growth will be compared according to the subjects' respective AMH levels.
干预措施: Follicular growth (Diagnostic Test)
Group B: CC & no ovulation
AMH level is measured before Clomiphene citrate 100 mg daily for 5 days & detecting Follicular growth assessment by TVU will be performed at day 12 of the menstrual period. Successful and unsuccessful follicular growth will be compared according to the subjects' respective AMH levels.
干预措施: Clomiphene Citrate (Drug)
Group B: CC & no ovulation
AMH level is measured before Clomiphene citrate 100 mg daily for 5 days & detecting Follicular growth assessment by TVU will be performed at day 12 of the menstrual period. Successful and unsuccessful follicular growth will be compared according to the subjects' respective AMH levels.
干预措施: Follicular growth (Diagnostic Test)
结局指标
主要结局
AMH in prediction of Ovulation in women with PCOS.
时间窗: 10 days
AMH level is measured 10 days before expected date of ovulation then correlated to ovulation either successfully or not.
次要结局
未报告次要终点
研究者
Narges Essam El-din Marrey
Resident of obs & gyn.
Ain Shams University