NCT03630562已完成不适用
Assay of Pro-angiogenic Cytokines in Exudative Age-Related Macular Degeneration
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Change of pro-angiogenic cytokines concentration in the aqueous humor of patients with exudative AMD at 3 months
研究概览
简要总结
Anti-VEGF intravitreal injections are the treatment of choice in age-related macular degeneration (AMD). However 37% of patients are unresponsive or poorly responsive to these therapies. It is still not possible to foresee the patient's response to anti-VEGF injections. A poor response may be related to an activation of alternative pro-angiogenic pathways with over expression of many other pro-angiogenic cytokines.
The primary goal of this study is to measure the aqueous humor concentration of pro-angiogenic cytokines in AMD patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years
- •Diagnosis of exudative age-related macular degeneration requiring intravitreal anti-VEGF treatment.
- •Patient for whom the last intravitreal injection of anti-VEGF in the eye is strictly more than 3 months
- •Signature of informed consent
- •Affiliation to the French social security system
排除标准
- •Pregnant or nursing patient (a urinary pregnancy test will be performed)
- •Systemic treatment with anti-VEGF
- •Intravitreal treatment with anti-VEGF for less than 3 months regardless of the treated eye.
- •Retinal pathology that can modify the secretion of pro-inflammatory cytokines such as diabetic retinopathy, venous occlusions, intermediate and posterior uveitis.
- •Diabetes Mellitus
- •High Myopia
- •Simultaneous participation in another clinical research protocol in exudative AMD
- •Person under guardianship, under curatorship, deprived of liberty
结局指标
主要结局
Change of pro-angiogenic cytokines concentration in the aqueous humor of patients with exudative AMD at 3 months
时间窗: At Month 3
次要结局
- Dose of VEGF in the aqueous humor of patients with exudative AMD(At Day 0, Month 1, Month 2, Month 3)
- Dose of pro inflammatory cytokines in the aqueous humor of patients with exudative AMD(At Day 0, Month 1, Month 2, Month 3)
- Measurement of visual acuity with Snellen chart(At Day 0, Month 1, Month 2, Month 3)
- Measurement of visual acuity with ETDRS visual acuity chart(At Day 0, Month 1, Month 2, Month 3)
研究者
研究点 (1)
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