Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- University of Florida
- Enrollment
- 150
- Locations
- 2
- Primary Endpoint
- Pressure Pain Thresholds
Study Overview
Brief Summary
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Ages 18-70
- •Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
- •Fulfills the 2010 ACR-EULAR classification criteria for RA
- •Healthy volunteers: No significant pain/fatigue/depression/anxiety.
Exclusion Criteria
- •Advanced liver, kidney or cardiovascular disease
- •Neuropathic pain
Arms & Interventions
Fibromyalgia
Participants who fulfill the 1990 and 2011 American College of Rheumatology Criteria for FM.
Rheumatoid Arthritis
Participants who fulfill the 2010 American College of Rheumatology (ACR)-European League against rheumatism (EULAR) classification criteria for RA.
Healthy Volunteers
Participants who do not have significant pain/fatigue/anxiety/depression.
Outcomes
Primary Outcomes
Pressure Pain Thresholds
Time Frame: One hour
Using an algometer pressure pain thresholds will be obtained several times at the upper and lower extremities
Secondary Outcomes
No secondary outcomes reported