Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Recruiting

• Conditions: Fibromyalgia; Rheumatoid Arthritis

• Registration Number: NCT05277025
• Lead Sponsor: University of Florida

Brief Summary

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-02-28
• Study First Submitted QC: 2022-03-11
• Study First Posted: 2022-03-14
• Study Start: 2022-03-22
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-14
• Last Update Posted: 2024-06-18
• Primary Completion: 2026-02-28
• Study Completion: 2026-02-28

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Ages 18-70
• Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
• Fulfills the 2010 ACR-EULAR classification criteria for RA
• Healthy volunteers: No significant pain/fatigue/depression/anxiety.

Exclusion Criteria

• Diabetes
• Cancer
• Advanced liver, kidney or cardiovascular disease
• Neuropathic pain

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pressure Pain Thresholds	One hour	Using an algometer pressure pain thresholds will be obtained several times at the upper and lower extremities

Trial Locations

Locations (1)

University of Florida; 🇺🇸 Gainesville, Florida, United States