A Randomized multicenter phase III trial comparing enzalutamide vs. a combination of Ra223 and enzalutamide in asymptomatic or mildly symptomatic castration resistant prostate cancer patients metastatic to bone.

Phase 1

Conditions: Castration resistant prostate cancer patients metastatic to bone.
MedDRA version: 21.1Level: PTClassification code 10036909Term: Prostate cancer metastaticSystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Therapeutic area: Diseases [C] - Cancer [C04]

Registration Number: EUCTR2014-001787-36-DK

Lead Sponsor: European Organisation for Research and Treatment of Cancer (EORTC)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Recruiting

Sex: Male

Target Recruitment: 446

Inclusion Criteria

? Histologically confirmed diagnosis of prostate adenocarcinoma
? Asymptomatic or mildly symptomatic (defined as short form question #3 in Brief Pain Inventory worst pain must be < 4.
? Metastatic to bone with = 4 bone metastases (ambiguous areas of increased uptake on 99mTC Bone Scan (BS) should be confirmed by CT or MRI) with or without additional lymph node metastases. Patients with visceral metastases are not allowed. Patients with multifocal bone lesions are allowed, while patients with diffuse confluent bone lesions (superscan) are not allowed in the trial.
Note: Patients must start treatment with a bone protecting agent (at doses used to reduce the incidence of skeletal related events) ideally before or at the time of randomization, if patient is not already on one. A minimum of two doses is recommended before the first administration of Ra223 in the experimental arm. The first administration of Ra223 should be scheduled at least 6 weeks after the first administration of bone protecting agent.
Note: For French sites only, patients must not have undergone a PET/CT scan for restaging prostate cancer using radiopharmaceuticals such as 18F-FDG, 18F-fluoride, 18F-Fluorocholine or a PSMA (prostate-specific membrane antigen) ligand or any other tracer.
? Progressive CRPC according to Prostate Cancer Working Group 3 (PCWG3) i.e. either:
-For patients who manifest disease progression solely as a rising PSA level, PCWG3 criteria require documentation of a sequence of rising PSA values at a minimum of 1-week intervals with the last value = 2 ng/mL.
-For patients with disease progression manifest in the bone, irrespective of progression by rising PSA, PCWG3 guidelines require appearance of 2 or more new lesions. Ambiguous results should be confirmed by other imaging modalities than bone scan (e.g.: CT-scan or MRI).
-For patients with disease progression manifest at nodal sites, irrespective of progression by rising PSA, PCWG3 requires progression according to RECIST 1.1.
? Ongoing androgen deprivation therapy (ADT) with luteinizing hormone-releasing hormone (LHRH) agonist or antagonist or bilateral orchiectomy.
Patients must be at least 18 years old
? WHO Performance status 0-1
? Charlson score = 3
? T-score = -2.5 on a DXA scan done in the past 12 months
? Castrate serum levels of testosterone < 50 ng/dL
? Biochemistry and hematology
-Adequate bone marrow function (absolute neutrophil count (ANC) = 1.5 109/L; platelets = 100 109/L, and hemoglobin = 10.0 g/dl.).
-Total bilirubin level = 1.5 x institutional upper limit of normal (ULN), except for patient with Gilbert’s disease where = 5.0 × ULN applies.
-Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) = 2.5 x ULN.
-Creatinine = 1.5 x ULN
-Albumin > 25 g/L
? Normal cardiac function according to local standard by 12-lead ECG (complete, standardized 12-lead recording).
? Able to swallow the study drug and comply with study requirements
? Prior or concomitant therapy.
-Prior docetaxel is permitted if given in the castration sensitive state and if it was started within 4 months of ADT initiation.
Note: patients having received docetaxel for CRPC are excluded.
? Prior use of abiraterone is permitted if the patient had a response or stable disease on abiraterone for a minimum of 1 year for metastatic castration sensitive prostate cancer
Note: patients having received abiraterone for CRPC are excluded.
? Prior treatment with abiraterone is allowed if it w

Exclusion Criteria

? Known central nervous system metastases or leptomeningeal tumor spread.
? Significant cardiovascular disease including:
-Myocardial infarction within 6 months prior to screening.
-Uncontrolled angina within 3 months prior to screening.
-Congestive heart failure New York Heart Association (NYHA) class III or IV, or patients with history of congestive heart failure NYHA class III or IV in the past, unless a screening echocardiogram or multi-gated acquisition scan (MUGA) performed within 3 months results in a left ventricular ejection fraction that is = 45%
-History of clinically significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes).
-History of Mobitz II second degree or third degree heart block without a permanent pacemaker in place.
-Uncontrolled hypertension as indicated by a resting systolic blood pressure > 140 millimeters of mercury (mm Hg) or diastolic blood pressure > 90 mm Hg at screening.
Note: Initiation or adjustment of antihypertensive medication(s) is permitted prior to randomization. Blood pressure must be re-assessed on two occasions that are separated by a minimum of 1 hour. The mean SBP / DBP values from all blood pressure assessment timepoints must be = 140/90 mm Hg in order for a patient to be eligible for the study.
-Hypotension as indicated by systolic blood pressure < 86 mm Hg at screening.
-Uncontrolled hyperglycemia as indicated by a fasting glucose = 7 mmol/L.
-Bradycardia as indicated by a heart rate of < 45 beats per minute on the screening ECG and on physical examination.
? Prior treatment with enzalutamide, apalutamide, darolutamide or Ra223.
? Concomitant treatment with Cyp17 inhibitors (abiraterone, orteronel) and ketoconazole.
? Prior hemibody external radiotherapy. Patients who received other types of prior external radiotherapy are allowed provided that the bone marrow function is assessed and meets the protocol requirements for hemoglobin, absolute neutrophil count and platelets.
? Prior therapy with other radionuclides (e.g., strontium-89, samarium-153, rhenium-186, or rhenium-188).
? Involvement in another therapeutic trial involving an experimental drug.
? Anticancer therapy (except ADT) or treatment with another investigational agent within the last 4 weeks prior to randomization.
? Known hypersensitivity to compounds related to enzalutamide or Ra223 .
? Prior history of malignancies other than prostate adenocarcinoma (except patients with basal cell, squamous cell carcinoma of the skin, in-situ carcinoma or low-grade superficial bladder cancer), or the patient has been free of malignancy for a period of 3 years prior to randomization date.
? History of seizure, including any febrile seizure, loss of consciousness, or transient ischemic attack within 12 months of randomization, OR any condition that may pre-dispose to seizure (e.g., prior stroke, brain arterio-venous malformation, head trauma with loss of consciousness requiring hospitalization).
? Major surgery within 4 weeks prior to treatment.
? Drug or alcohol abuse.
? Other serious illness or medical condition, such as but not limited to:
-Any infection = Grade 2 according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 4.
-No gastrointestinal disorder affecting absorption (e.g., gastrectomy or active peptic ulcer disease).
-Crohn’s disease or ulcerative colitis.
-Osteonecrosis of the jaw.
-An

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method

Secondary Outcome Measures

Name	Time	Method