Sugammadex versus neostigmine for antagonism of rocuronium-induced neuromuscular blockade in cirrhotic patients undergoing liver resectio

Not Applicable

• Conditions: Circulatory System; Surgery; Cirrhotic patients after liver resection

• Registration Number: PACTR201411000912262
• Lead Sponsor: ational liver institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-10-19
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

American Society of Anesthesiologists physical status class I-III (Class I in patients with preoperative normal liver functions).
Thirty patients categorized as Child classification ¿A¿ with a Model for End-Stage Liver Disease (MELD) score <10. Additional 30 patients with normal preoperative liver functions will serve as controls

Exclusion Criteria

Co-existing neuromuscular disease, body mass index more than 35 kg/m-2, renal impairment, medications known to affect neuromuscular transmission e.g. aminoglycoside antibiotics or magnesium sulphate, bleeding tendency, and intraoperative events e.g. (massive bleeding and hypothermia).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The time from the start of sugammadex or neostigmine administration to recovery of the TOF ratio to 0.9

Secondary Outcome Measures

Name	Time	Method
Duration of anaesthesia and surgery.;Total dose of rocuronium.