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Influence of inspiratory time in preterm infants <32 SSW with respiratory distress syndrome on respiratory mechanics and homogeneity of lung ventilatio

Not Applicable
Conditions
Respiratory mechanics and homogeneity of lung ventilation
Registration Number
DRKS00029705
Lead Sponsor
niversitätsklinikum Freiburg
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Pending
Sex
All
Target Recruitment
10
Inclusion Criteria

Gestational age < 32 bw, chronological age < 8 d, invasive ventilation (conventional ventilation or HFO) because of respiratory distress syndrome (radiologic, surfactant administration), tube leak less than 30%, signed informed consent from guardian.

Exclusion Criteria

Severe connatal pulmonary or cardiac malformations, chromosomal abnormalities, respiratory failure under invasive ventilation (pCO2 > 70 mmHg, FiO2 > 0.7).

Study & Design

Study Type
interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Influence of inspiratory time on gas flow and airway pressure measured by intratidal respiratory mechanics analysis
Secondary Outcome Measures
NameTimeMethod
Determination of the variability of time constants in preterm infants, influence of inspiratory time on compliance and resistance using intratidal respiratory mechanics analysis, influence of inspiratory time on transpulmonary pressures, influence of inspiratory time on the required inspiratory pressure at constant tidal volume, and influence of inspiratory time on lung ventilation measured by electrical impedance tomography.
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