NT-proBNP and Troponin I in Children With Dengue Hemorrhagic Shock: a Longitudinal Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Concentration of NT-proBNP
研究概览
简要总结
To discribe concentration of NT-proBNP and Troponin I in Dengue hemorrhagic shock children, in correlation between concentration of NT-proBNP and troponin I with total fluid admission, respiratory support, using inotrope and vasopressor using.
详细描述
Treatment of children with Dengue hemorrhagic shock syndrome (DSS) is challenge, especially in cases with hypotensive shock, profound shock or whom do not have a response to initial crystalloid therapy. Currently, treatment of DSS remains almost supportive, with particular emphasis on careful fluid management. However, fluid overload is a common complication of this treatment, lead to many difficulties in management of severe Dengue children, accompany with morbidity and mortality. Diagnosis of fluid overload mostly based on clinical features and chest X-ray or ultrasound. Until now, no biomarker are widely using for diagnosis of fluid overload in clinical. NT-proBNP is secreted when stretching the wall of the cardiac muscle. This may a suitable biomarker to discover the fluid overload state in children with DSS. Troponin I is a biomarker of cardiac muscle damage.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Dengue shock children who admitted to ICU
排除标准
- •Excluding the cases of children with cardiovascular disease, hyperthyroidism, taking drugs such as insulin, steroid, estrogen, growth hormone, thyroid hormone
结局指标
主要结局
Concentration of NT-proBNP
时间窗: 10 days
Concentration of NT-proBNP in Children with Dengue hemorrhagic shock and severe shock
Concentration of Troponin I
时间窗: 10 days
Concentration of Troponin I in Children with Dengue hemorrhagic shock and severe shock
次要结局
- Correlation between concentration of NT-proBNP(14 days)
- Rate of MAC ELISA IgM Dengue(14 days)
- Rate and kind of Vancomycin using(14 days)
- Rate of CRRT(14 days)
- Rate of abnormal liver, kidney, hematology laboratory exam(14 days)
- Rate and kind of cephalosporin using(14 days)
- Cut-off value of NT-proBNP for fluid overload(14 days)
- Rate of NS1 Dengue(10 days)
- Rate of respiratory support(14 days)
- Rate of intubation(14 days)
- Rate of intraperitoneal fluid drainage(14 days)
- Rate of mode of ventilation(14 days)
- Total fluid administration(14 days)
- Time for IV fluid administration(14 days)
- Correlation between concentration of Troponin I(14 days)
- Rate of clinical manifestations(14 days)
- Rate of abnormal laboratory exam(14 days)
- Rate of complications(14 days)
- Rate and kind of Carbapenem using(14 days)
研究者
Le Phuoc Truyen
Clinical Physician
University of Medicine and Pharmacy at Ho Chi Minh City