Evaluation of electrical cardiometry to assess fluid responsiveness by tracking PLR-induced change in cardiac output in patients with acute circulatory failure: A comparison study with transthoracic echocardiography
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 125
- 试验地点
- 1
- 主要终点
- To measure bias, mean, and limits of agreement for cardiac output obtained with Electrical cardiometry and those obtained by transthoracic echocardiography, before and after passive leg raising in patients with acute circulatory failure.
研究概览
简要总结
sepsis is common in intensive care patients and such patients receive fluids as initial care to maintain blood pressure and ensure adequate oxygen delivery to the tissues. However, only 50% of patients respond to fluid administration and excess of fluid has shown to cause harm. Therefore, identification of fluid responders is important. There are multiple techniques to assess fluid responsiveness and change in cardiac output after passive leg raising is one of them. It is simple and does not cause harm by avoiding exogenous administration of fluids. Electrical cardiometry is simple, easy to use and non-invasive device and can be used in place of transthoracic echocardiography for monitoring change in cardiac output. This study aims to evaluate the role of electrical cardiometry for trending of cardiac output in patients with acute circulatory failure.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients (18-65 years) with an arterial catheter in situ, on controlled mechanical ventilation and at least one of the following signs of circulatory failure: 1.systolic blood pressure ≤ 90 mmHg or fall > 50 mm Hg in previously hypertensive patients 2.The requirement of vasopressor drugs 3.urine output ≤ 0.5 ml/kg/hr during at least two hours 4.Heart rate > 100 beats/minute 5.Presence of skin mottling or delayed capillary refilling (> 3 seconds).
排除标准
- •age<18 years and >65 years
- •pregnancy
- •patient with arrhythmias
- •known case of heart failure on treatment
- •patients with lower limb amputation
- •patient with valvular heart diseases
- •contraindications to performing PLR (Lower limb DVT, Limb/pelvic fracture, abdominal surgeries, intra-abdominal hypertension, intracranial hypertension
- •presence of wound/dressing in the neck
- •difficulty in getting adequate echo window (morbid obese[BMI> 40 Kg/square metre],chest wall trauma).
结局指标
主要结局
To measure bias, mean, and limits of agreement for cardiac output obtained with Electrical cardiometry and those obtained by transthoracic echocardiography, before and after passive leg raising in patients with acute circulatory failure.
时间窗: the outcome will be assessed at the end of study period
次要结局
- a.To measure the change in heart rate, systolic, diastolic, mean arterial pressure, and Central venous pressure(b.To measure the change in ventilatory parameters (peak airway pressure and mean airway pressure))