NCT00432393已完成4 期
Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 试验地点
- 2
研究概览
简要总结
Purpose: There are some controversies about the effect of Levodopa-Carbidopa on treatment of non-arteritic anterior ischemic optic neuropathy (NAION). This study was performed to evaluate the effect of Levodopa-Carbidopa on visual acuity, color vision, and visual field in patients with recent onset NAION (less than 6 weeks duration).
Patients and Methods: In this double-blind randomized clinical trial, 13 patients were treated with levodopa-carbidopa and 12 patients took placebo for 3 weeks. Visual acuity, color vision, and visual field were tested before and at 4th, 12th, 16th, and 24th weeks after enrollment, and evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age greater than 50 years old
- •first ophthalmic examination within 6 weeks after onset of disease
- •presence of optic disc swelling followed by optic atrophy within 6 weeks
- •altitudinal, central or generalized visual field defect
- •normal ESR
排除标准
- •confirmed giant cell arteritis
- •history of any ocular surgeries
- •optic neuropathy due to acute bleeding
- •advanced diabetic retinopathy
- •uncontrolled glaucoma
- •any ocular disorders that cause visual acuity reduction rather than NAION
研究者
研究点 (2)
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