Early spontaneous breathing in ARDS
Recruiting
- Conditions
- J80Adult respiratory distress syndrome
- Registration Number
- DRKS00031486
- Lead Sponsor
- niversitätsklinikum des Saarlandes
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
invasively ventilated for >24 hours
expected to be invasively ventilated for >24 hours
oxygenation index <200mmHg despite adequate PEEP
Hamilton C6 respirator used
tube ID at least 7mm and with subglottic suction
Pes probe for pressure measurement available
sedation with isoflurane
no effect of relaxation anymore
project staff available
Exclusion Criteria
patients of minor age
patients unable to give informed consent
contraindication to spontaneous breathing (f.e. intracranial pressure, chest wall instability)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of pressure supported spontaneous breathing in patients with severe and moderate ARDS during the first 24 hours of invasive ventilation
- Secondary Outcome Measures
Name Time Method 1. Description of the spontaneous breathing pattern (respiratory rate, tidal volumes, esophageal pressures),<br>2. detection of drug dosages (isoflurane and remifentanil) and of the arterial CO2 partial pressure, when spontaneous breathing is starting,<br>3. identification of factors that facilitate or else impede spontaneous breathing,<br>4. identify the reasons, why spontaneous breathing cannot be installed/must be interrupted.