CTP Imaging of Lung Cancer

Completed

• Conditions: Non Small Cell Lung Cancer

• Registration Number: NCT01823094
• Lead Sponsor: University of California, Davis

Brief Summary

Investigators hope to learn more about how to use computed tomography (CT) scans to measure blood flow in lung tumors and how it may change in response to treatment. This measurement technique is called computed tomography perfusion (CTP). CT scanners use X-rays to produce 3-dimensional images of the body.

Currently, doctors determine the response to treatment by measuring the size of the tumor. Investigators are trying to find out if measuring the blood flow in the tumor is equal to or better than measuring the size of the tumor.

Detailed Description

This is an experimental study of CT perfusion (CTP) imaging in subjects with non-small cell lung cancer. The objectives of this study are to demonstrate the feasibility of CT blood flow measurements in lung cancer, to develop a foundation for the use of CT blood flow measurements in lung cancer to assess the response to treatment, and to develop an optimized CTP imaging protocol for evaluating blood flow in solid body tumors. In this study, tumor blood flow will be evaluated at baseline and follow-up routine CT examinations of patients with non-small cell lung cancer, and the response of tumor blood flow will be recorded as a secondary endpoint. This research study will entail two study visits - one required and one optional - which will coincide with regularly scheduled standard of care CT scans.

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-03-22
• Study First Submitted QC: 2013-03-28
• Study First Posted: 2013-04-04
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Status Verified: 2016-01
• Last Update Submitted: 2016-01-22
• Last Update Posted: 2016-01-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

adult patients with non small cell lung cancer who receive, or are considered for, systemic therapy

Exclusion Criteria

renal failure pregnancy known contrast allergy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Yield of conducting CTP studies	2 years	Yield is determined as the percentage of assessable CTP studies, relative to all performed studies

Secondary Outcome Measures

Name	Time	Method
Variability of CTP measurements	2 years	Variability will be determined from two consecutively acquired CTP examinations, and repeated analyses of the same studies
Magnitude of treatment induced changes in tumor blood flow	2 years	The magnitude of treatment induced changes in blood flow will be determined from comparisons of bloodflow before and after treatment

Trial Locations

Locations (1)

University of California, Davis Medical Center; 🇺🇸 Sacramento, California, United States