Efficacy of Vitamin C Supplementation on Malondialdehid Levels and Disease Activity in SLE Patients
- Conditions
- Systemic Lupus Erythematosus (SLE)
- Registration Number
- NCT07083622
- Lead Sponsor
- Universitas Sriwijaya
- Brief Summary
The study aimed to evaluate the efficacy of vitamin C supplementation compared to placebo towards malondialdehid levels and disease activity with the MEX-SLEDAI score in Systemic Lupus Erythematosus (SLE) patients. The current study was designed as a single-center double-blind randomized controlled clinical trial. The participants were voluntarily recruited ≥ 18 years old SLE patients, with mild to moderate disease activity and did not consumed vitamin C 1 week prior to the trial study. Participants were randomized into two groups receiving vitamin C supplementation, or placebo. Malondialdehid levels and MEX-SLEDAI score were evaluated at the beginning and at the end of the 8 week trial for analysis.
- Detailed Description
This research is a double blind randomized controlled trial study. The study subjects were 38 patients diagnosed with mild to moderate lupus activity, randomly divided into 2 groups, who received vitamin C supplementation twice daily for 8 weeks and the group that received placebo. Serum malondialdehid levels and the degree of disease activity using MEX-SLEDAI score were measured before and after treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 38
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method MEX-SLEDAI From enrollment to the end of the treatment at 8 weeks To determine the effectiveness of adding vitamin C compared to placebo towards disease activity in SLE patients, measured with MEX-SLEDAI score
Malondialdehid From enrollment to the end of the treatment at 8 weeks To determine the effectiveness of adding vitamin C compared to placebo towards malondialdehid levels concentration change in SLE patients.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mohammad Hoesin General Hospital
🇮🇩Palembang, South Sumatera, Indonesia
Mohammad Hoesin General Hospital🇮🇩Palembang, South Sumatera, Indonesia