Randomized and controlled clinical trial of the efficacy and safety of the use of lidocaine and magnesium sulfate for lung resection surgery using Video-Assisted Thoracic Surgery (VATS)

Phase 1

• Conditions: ung resection surgery using Video-Assisted Thoracic Surgery (VATS); Therapeutic area: Diseases [C] - Respiratory Tract Diseases [C08]

• Registration Number: CTIS2023-509503-33-00
• Lead Sponsor: Clinica Universidad De Navarra

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-30
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 128

Inclusion Criteria

Patients undergoing lung tumor resection surgery using video-assisted thoracoscopy., The patient must be 18 years of age or older., The patient, or his or her representative, has given consent to participate in the study., The patient must, in the opinion of the investigator, be able to comply with all the requirements of the clinical trial.

Exclusion Criteria

Patients who have previously been diagnosed with chronic pain prior to surgery., Patients unable to clearly understand the objectives and methodology of the study., Patients with chronic kidney damage with glomerular filtration < 60 ml/min (stage III-V)., Patients with liver dysfunction with total bilirubin > 3mg/dL., Expected surgery lasting more than 6 hours or no extubation plan immediately after surgery., Patients with < 45kg and > 100kg., Pregnant or breastfeeding women., History of hypersensitivity to any of the components of lidocaine or magnesium sulfate., Patients who for some medical reason are contraindicated in the use of lidocaine or magnesium sulfate., Patients who are taking analgesics (paracetamol or non-steroidal anti-inflammatory drugs or opioids) in the 7 days prior to surgery., History of alcohol or drug abuse or psychiatric illness., History of Congestive Heart Failure or ejection fraction <50% or atrioventricular heart block., Disease of the central nervous system., Porphyria.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified