Sevoflurane-Remifentanil Anaesthesia. The Risk of Post Operative Nausea
- Conditions
- NauseaVomiting
- Registration Number
- NCT00452855
- Lead Sponsor
- Central Jutland Regional Hospital
- Brief Summary
The purpose of this study is to determine whether sevoflurane-remifentanil anaesthesia is similar to propofol-remifentanil anaesthesia concerning post- operative nausea and vomiting.
- Detailed Description
Propofol and sevoflurane anaesthesia are used world wide at the anaesthetists discretion.
Propofol is superior to inhalational anaesthetics as anaesthesia for patients at risk of post operative nausea and vomiting (PONV) as PONV is diminished. However, when remifentanil is used as adjuvant to sevoflurane, the total dose of the latter is reduced.
Therefore, we wanted to investigate if sevoflurane-remifentanil anaesthesia is similar to propofol-remifentanil anaesthesia with emphasis on nausea, vomiting and total PONV during 24 hours.
In the post anaesthesia care unit (PACU) and in the surgical ward nausea was scored on a visual analogue score. Vomiting was registered.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 160
- Females younger than 50 years
- ASA I-II
- Scheduled to gynaecological laparotomies or laparoscopies
- Medication known to act anti-emetic
- ASA status greater than II
- Malignant hyperthermia
- Allergy to the drugs used.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Nausea, incidence and intensity ( VAS score )in PACU and surgical ward Vomiting, incidence in PACU and surgical ward Total PONV after 24 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Viborg Hospital
🇩🇰Viborg, Denmark