BIOEQUIVALENCE STUDY 2010 Comparison of the absorption of MK-7 after intake of 3 different existing MK-7 supplements

Completed

Conditions: Vitamin K2 deficiency
10047635

Registration Number: NL-OMON34781

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 24

Inclusion Criteria

* Healthy men and women, aged between 20 and 40 years
* Normal body weight and height (18.5 kg/m2 < BMI <30 kg/m2)
* Stable body weight (weight gain or loss <3 kg in past 3 mo)
* Written consent to take part in the study
* Agreement to adhere to dietary restrictions required by the protocol

Exclusion Criteria

* Abuse of drugs and/or alcohol
* Use of vitamin supplements containing vitamin K
* Soy allergy
* Pregnancy
* (a history of) metabolic or gastrointestinal diseases including hepatic disorders
* Chronic degenerative and/or inflammatory diseases, e.g. diabetes mellitus, renal failure
* Use of oral anticoagulants
* Corticoid treatment
* Subjects with anaemia or subjects who recently donated blood or plasma
* Systemic treatment or topical treatment likely to interfere with coagulation metabolism (salicylates, antibiotics)
* Chronic degenerative and/or inflammatory diseases
* Use of oral anticoagulants
* Corticoid treatment
* Systemic treatment or topical treatment likely to interfere with evaluation of the study parameters

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Circulating MK-7 levels will be measured at the various points in time: at<br /><br>baseline (before sampling), and 2, 4, 6, 8, 24, 48 and 96 hours after MK-7<br /><br>supplementation to determine the MK-7 absorption profiles.</p><br>

Secondary Outcome Measures