Attention and Grouping of Visual Information: What is Disturbed in Patients With Schizophrenia?
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Schizophrenia
- 发起方
- University Hospital, Strasbourg, France
- 入组人数
- 52
- 试验地点
- 1
- 状态
- 已完成
- 最后更新
- 15年前
概览
简要总结
The main objective of the study is to contribute to a better understanding of the physiopathology of schizophrenia, by studying causal relationships between cognitive deficits and the neurobiological basis for these deficits. Processing visual information involves both automatic grouping processes and control processes. Automatic grouping processes allow the building of a global configuration from local contour information. It is necessary in order to recognize objects. Control processes allow tending to and prioritizing information parts. The paradigm the investigators use allows to dissociate these processes, and is used in order to characterize the impairments observed in patients with schizophrenia. It is adapted to fMRI in order to explore the neurobiological basis of the deficits. The investigators will examine whether functional disconnectivity between activated areas subtend the impairments observed in patients.
研究者
入排标准
入选标准
- •Patients with schizophrenia (DSM-IV criteria)
- •Healthy controls matched with patients on age, sex and education level
- •Ages 18 to 50
- •Signed informed consent
- •Right-handed
排除标准
- •No severe somatic illness
- •No invalidating sensory disease
- •No drug abuse, as defined by DSM-IV criteria
- •No general anaesthesia in the past 3 months
- •No intake of drugs affecting the CNS, except for patients
结局指标
主要结局
未指定