The effects of spironolactone on endothelial function, autonomic function and glycaemic control in diabetic patients with poor blood pressure control

Completed

• Conditions: Type 2 diabetes mellitus and hypertension; Circulatory System

• Registration Number: ISRCTN76558770
• Lead Sponsor: Tenovus Scotland (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-07-27
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Patients with type 2 diabetes mellitus and hypertension who were on standard treatment were recruited. All patients were on either Angiotensin Converting Enzyme (ACE) inhibitors or angiotensin receptor blockers.

Exclusion Criteria

1. Blood pressure <140 mm Hg systolic and 80 mm Hg diastolic
2. Recent admission to hospital within last 4 weeks
3. History of alcohol abuse
4. Liver or renal impairment
5. Heart failure
6. On potassium sparing diuretics, insulin or warfarin (procedural risks)

Study & Design

• Study Type: Interventional
• Study Design: Not specified