Clinical and molecular characterization of childhood cancer susceptibility syndromes

• Conditions: childhood cancer; paediatric malignancies; 10027656

• Registration Number: NL-OMON30743
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Patients with childhoodcancer and
- a congenital defect and/or
- developmental delay and/or
- dysmorphisms and/or
- a positive family history for cancer (sibs with childhood cancer or a parent with cancer at an age younger than 50 years)

Exclusion Criteria

Cancer predisposition syndromes with a known molecular cause, for example Bechwith Wiedemann syndrome

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Putative novel childhood malignancy predisposing genes.<br /><br></p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Knowledge, experience and guidelines for the recognition and counseling of the<br /><br>hereditary character of childhood malignancy.</p><br>