Comparison of efficacy and tolerability of three different drugs in patients of schizophrenia
Phase 4
- Conditions
- Health Condition 1: F209- Schizophrenia, unspecified
- Registration Number
- CTRI/2024/07/071231
- Lead Sponsor
- Harry Babu
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Inclusion Criteria:
-Newly diagnosed patients of schizophrenia as diagnosed by psychiatrist according to DSM 5 criteria.
-PANSS score between 80-120 at baseline
-Patients/Legally Acceptable Representative (LAR) willing to give written informed consent
-Either gender aged between 18-70 years
Exclusion Criteria
1)Patients on medications known to interact significantly with any of the study drugs
2)Dementia related Psychosis
3)Seizure Disorder
4)Patients with history suggestive of:
a)Severe Liver/Kidney Damage
b)Substance dependence
5)Pregnant and lactating women
6)Patients on multidrug therapy for schizophrenia (more than one drug from the above mentioned)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate and compare the efficacy of Cariprazine, Risperidone & Olanzapine in patients of schizophrenia by comparing mean change in PANSS & BPRS score.Timepoint: 0,3,6,12 weeks
- Secondary Outcome Measures
Name Time Method ADHERENCE <br/ ><br>To assess and compare adherence to therapy with Cariprazine, Risperidone & Olanzapine in patients of Schizophrenia using MARS adherence scaleTimepoint: 03,06,12 WEEKS;QUALITY OF LIFE <br/ ><br>To compare effect of Cariprazine, Risperidone & Olanzapine on quality of life in patients of Schizophrenia using abbreviated version of Heinrich carpenter quality of life scale.Timepoint: 0,3,6,12 WEEKS;TOLERABILITY <br/ ><br>To compare effect of Cariprazine, Risperidone & Olanzapine on quality of life in patients of Schizophrenia using abbreviated version of Heinrich carpenter quality of life scaleTimepoint: 03.06,12 weeks