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Effect of Regular Physical Activity in Normal-Weight Individuals With Type 2 Diabetes and Abdominal Obesity

Completed
Conditions
Diabetes (DM)
Physical Activity
Registration Number
NCT07071545
Lead Sponsor
Samsung Medical Center
Brief Summary

Individuals with T2DM accompanied by abdominal obesity tend to experience worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators conducted a retrospective cohort study using data from the Korean National Health Insurance Service (K-NHIS) database to evaluate the impact of regular physical activity.

Detailed Description

It is well established that patients with T2DM and abdominal obesity have worse clinical outcomes. This holds true even among individuals with a normal body weight but central (abdominal) obesity. In this study, the investigators aimed to determine whether engaging in regular physical activity (defined as vigorous exercise at least three times per week) is associated with improved clinical outcomes in normal-weight individuals with abdominal obesity. Specifically, we compared the incidence of MACCE between normal-weight patients with type 2 diabetes who had abdominal obesity and those who did not.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
249247
Inclusion Criteria
  • Patients who were newly diagnosed with T2DM and had a normal body weight at the time of diagnosis.
Exclusion Criteria
  • Patients with any pre-existing diabetes-related complications
  • Patients who were overweight or obese based on BMI criteria

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Major adverse cardiac and cerevrovascular events (MACCE)10 years after diagnosed T2DM

Composite of all-cause death, myocardial infarction, ischemic stroke, heart failure

Secondary Outcome Measures
NameTimeMethod
All cause death10 years after diagnosed T2DM

Death from all cause

myocardial infarction10 years after diagnosed T2DM

MI with hospitalization

Ischemic stroke10 years after diagnosed T2DM

Ischemic stroke after diagnosed T2DM

Heart failure10 years after diagnosed T2DM

HF with hospitalization

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