Haploidentical donor stem cell transplantation for haematological malignancies - a Phase 1/2 pilot study in an Australian populatio

Phase 1

Completed

• Conditions: Haematological malignancies; Blood - Haematological diseases; Cancer - Lymphoma (non Hodgkin's lymphoma) - High grade lymphoma; Cancer - Leukaemia - Acute leukaemia

• Registration Number: ACTRN12613000338763
• Lead Sponsor: St Vincent's Hospital,Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-03-27
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

ongoing complete remission of underlying haematological malignancy
Absence of a 100% matched or single-mismatch related donor or single umbilical cord blood with 4/6 HLA match.
Presence of 1 haploidentical famiy donor
Absence of active fungalor viral (inc CMV) infection.
ECOG<2
Preserved cardiac/renal/liver function

Exclusion Criteria

Life expectance <3 months.
Psychiatric condition interfering with informed consent.
History of active malignant disease within 5 yrs excl SCC or BCC of skin.
Previuos allogeneic stem cell transplant
Taking other 'investigational' drugs

Study & Design

• Study Type: Interventional
• Study Design: Not specified