This study is to determine whether cfDNA and DNA integrity Index have any role in managaement of colon cancerIn response to surgery, cfDNA and DNA integrity index may play a key role in determining the outcome of colon cancer patients
Not Applicable
Completed
- Conditions
- Health Condition 1: K638- Other specified diseases of intestine
- Registration Number
- CTRI/2023/10/058468
- Lead Sponsor
- Regional Cancer Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Pathologically diagnosed patients with colon cancer
primary resection
Stage T1-4, N1-2, M0
consent to participate in the study
Exclusion Criteria
WBC >10000
coexisting 2nd malignancy (other than colon cancer)
acute and chronic infectious conditions(including septicemia)
mental illness who could not cooperate with normal medical activities.
chronic diseases: renal (CRF), hepatic(CLD), and heart (CAD)
autoimmune diseases
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the level of cfDNA at baseline and after curative resection in patients with colon cancerTimepoint: before surgery and 4 weeks after surgery
- Secondary Outcome Measures
Name Time Method 1) The clinical & tumor related factors deciding baseline cf DNA levels <br/ ><br> 2) The clinical & tumor related factors affecting the DNA integrity index <br/ ><br> 3) To compare cfDNA with CEA level in response to surgery & correlate their levels <br/ ><br>Timepoint: before surgery & 4 weeks after surgery