MANTA-TRIAL; Randomized Controlled Trial of laparoscopic Toupet versus Anterior Fundoplication for Gastroesophageal Reflux Disease
Completed
- Conditions
- dysphagiareflux1001794310017998
- Registration Number
- NL-OMON39080
- Lead Sponsor
- Sint Antonius Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 94
Inclusion Criteria
- Age >= 18 years
- Proven gastroesophageal reflux disease by either endoscopy or 24 hour pH monitoring.
- Clinically indicated anti-reflux surgery
- Fit for surgery
- Reflux disease inadequately controlled by medication of unwillingness to take lifelong medication
Exclusion Criteria
- Age < 18 years
- No informed consent
- Previous anti-reflux surgery
- Large hiatus hernia ( more than 50% of the stomach in the chest)
- Pregnant
- Esophageal aperistalsis
- Esophageal spasms or achalasia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Objective reflux control, dysphagia and gas related symptoms are the main study<br /><br>endpoints. </p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms underlying the efficacy of laparoscopic Toupet versus anterior fundoplication in GERD patients with dysphagia?
How does laparoscopic Toupet compare to anterior fundoplication in managing gastroesophageal reflux disease with hiatal hernia subtypes?
What biomarkers predict long-term success of laparoscopic fundoplication techniques in chronic reflux disease management?
What are the potential adverse events associated with laparoscopic Toupet and anterior fundoplication for GERD treatment?
Are there comparative effectiveness studies of laparoscopic Toupet versus anterior fundoplication in relation to standard-of-care GERD therapies?