Probing Neural Circuitry for the Control of Movement

Completed

• Conditions: Neurological Movement Disorders

• Registration Number: NCT02150642
• Lead Sponsor: University of Zurich

Brief Summary

The investigators are interested in examining 1) the basic organization of spinal and cortical circuitry for the control of movement and 2) the influence of injury of these circuits. To investigate the neuronal circuitry, the investigators use various types of mechanical or electrical stimulation of the limbs, transcranial magnetic stimulation of the cortex and galvanic vestibular stimulation in both uninjured human subjects and subjects with a neurological injury (such as spinal cord injury, or Parkinsons's disease).

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2004-05
• Study First Submitted: 2014-05-14
• Study First Submitted QC: 2014-05-27
• Study First Posted: 2014-05-30
• Primary Completion: 2020-07-31
• Study Completion: 2020-07-31
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-14
• Last Update Posted: 2022-08-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• control subjects: no neurological movement disorder
• patients: neurological movement disorder

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Exclusion Criteria

patients and control subjects:

• presence of any central psychiatric disorder that precludes subject from giving informed and voluntary consent
• presence of any cardiovascular conditions or limitations that restrict the ability to walk on a treadmill continuously for more than 20 minutes
• for the electrical stimulation examination, subjects with metal implants are also excluded
• for the TMS and GVS examination, subjects with the following conditions are excluded: metal implants in the head, cardiac pacemakers, history of migraine headaches, history of major head injury, history of stroke, history of seizures, previous brain neurosurgery, unstable medical conditions, major psychiatric disorders, pregnancy -

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Spinal reflex activity	one day	Spinal reflex activity will be assessed by electrical nerve stimulation

Trial Locations

Locations (1)

University of Zurich; 🇨🇭 Zurich, Switzerland