NCT02150642已完成不适用
Probing Neural Circuitry for the Control of Movement
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Spinal reflex activity
研究概览
简要总结
The investigators are interested in examining 1) the basic organization of spinal and cortical circuitry for the control of movement and 2) the influence of injury of these circuits. To investigate the neuronal circuitry, the investigators use various types of mechanical or electrical stimulation of the limbs, transcranial magnetic stimulation of the cortex and galvanic vestibular stimulation in both uninjured human subjects and subjects with a neurological injury (such as spinal cord injury, or Parkinsons's disease).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •control subjects: no neurological movement disorder
- •patients: neurological movement disorder
排除标准
- •patients and control subjects:
- •presence of any central psychiatric disorder that precludes subject from giving informed and voluntary consent
- •presence of any cardiovascular conditions or limitations that restrict the ability to walk on a treadmill continuously for more than 20 minutes
- •for the electrical stimulation examination, subjects with metal implants are also excluded
- •for the TMS and GVS examination, subjects with the following conditions are excluded: metal implants in the head, cardiac pacemakers, history of migraine headaches, history of major head injury, history of stroke, history of seizures, previous brain neurosurgery, unstable medical conditions, major psychiatric disorders, pregnancy -
结局指标
主要结局
Spinal reflex activity
时间窗: one day
Spinal reflex activity will be assessed by electrical nerve stimulation
次要结局
未报告次要终点
研究者
研究点 (1)
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