Which Place for High Flow Oxygen in ICU ?

Not Applicable

Completed

• Conditions: Hypoxemia
• Interventions: Device: Optiflow

• Registration Number: NCT02080208
• Lead Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Brief Summary

Patients with respiratory failure often need oxygen and/or ventilatory support. Patients who need only oxygen support, usually received low flow oxygen (\< 15 Liters / min), as well as in respiratory weaning. Now new devices can be used. They provide high flow oxygen with different benefits. This high flow devices provide exact fraction of inspired oxygen (FiO2), allows a positive end expiratory pressure and supplies a wash out flow. The hypothesis of this study is that the high flow oxygen enable more efficient oxygen administration than conventional oxygen. In addition, it would improve the effectiveness of the ventilation of the patient, through flushing the dead space.

Detailed Description

The investigators hypothesized that when using high flow oxygen therapy, respiratory failure is relieved, as well as ventilation failure, so accessories are less stressed muscles, and this can be demonstrated by the electromyography (EMG) of sterno-mastoid..

Study Timeline

• Study Start: 2011-02
• Primary Completion: 2013-06
• Study Completion: 2013-06
• Study First Submitted: 2014-01-09
• Study First Submitted QC: 2014-03-04
• Study First Posted: 2014-03-06
• Status Verified: 2016-01
• Last Update Submitted: 2016-01-29
• Last Update Posted: 2016-02-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

patients with respiratory failure.

• Spontaneously breathing patient requiring administration at least 40% oxygen, or,
• Patient under mechanical ventilation, during respiratory weaning.

Exclusion Criteria

• Facial trauma, active hemoptysis, pneumothorax, thoraco-abdominal surgery or upcoming intubation for spontaneously breathing patients.
• Neuromuscular disease, altered consciousness or agitation for patients under mechanical ventilation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High Flow Oxygen	Optiflow	Patients receiving oxygen via high flow oxygen therapy (Optiflow)

Primary Outcome Measures

Name	Time	Method
Change from baseline in Oxygenation criteria	20 minutes	Arterial oxygen partial pressure (PO2), oxygen saturation by pulse oximetry (SpO2), arterial PO2/FiO2, positive end expiratory pressure (PEEP)

Secondary Outcome Measures

Name	Time	Method
Change from baseline in Ventilation criteria	20 minutes	respiratory rate (RR), arterial partial CO2 pressure (PCO2), pH, sterno-mastoid EMG