The underlying role of the social decision making network in impulsive aggressio

Completed

Conditions: Intermittent explosive disorder
10034726

Registration Number: NL-OMON45615

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

- Age 18-55 years
- Male
- Native Dutch speaker
- Right-handed
- Normal or corrected to normal vision
For patients:
- Score of >= 5 on the Social Dysfunction Aggression Scale (SDAS)
- Outpatient, meeting DSM-5 criteria or the integrated research criteria for Intermittent Explosive Disorder (IED-IR)

Exclusion Criteria

General exclusion criteria for fMRI: Metal implants or splinters, surgical clips, prostheses, artificial heart valves, claustrophobia, electronic equipment in body (such as a pacemaker), pregnancy, and epilepsy. ;Furthermore, a potential subject who meets any of the following criteria will be excluded from participation in this study:
Psychiatric
• Current major depression, or ADHD
• Lifetime history of bipolar disorder, schizophrenia, delusional disorder, schizoaffective disorder, schizopheniform disorder or other psychotic disorders
• Schizoid or schizotypical personality disorder
• Current alcohol- or substance dependence
• Mental retardation (IQ<70 estimated)
Somatic
• History of trauma capitis
• Neurological disorders

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary objective is to elucidate the role of the social decision making<br /><br>network and more specifically, the mesolimbic reward circuit and<br /><br>cortical-amygdala connections in IED patients compared to healthy controls. Our<br /><br>main question is whether an imbalance in the social decision network underlies<br /><br>increased reward sensitivity, decreased avoidance behaviour and increased<br /><br>reactivity to angry faces in IED patients. The main outcome measures will be<br /><br>drawn from functional magnetic resonance imaging (fMRI) scans, in which brain<br /><br>reactivity will be linked to the reaction time in rewarding vs. non-rewarding<br /><br>trials in a monetary incentive delay (MID) task, the number of avoidances in an<br /><br>approach-avoidance task (AAT), and emotional face processing. Furthermore,<br /><br>structural and resting state scans will be performed. </p><br>

Secondary Outcome Measures