NCT00370032已完成4 期
A Randomize, Placebo-controlled, Crossover Study to Measure the Effect of Alosetron on Mucosal Blood Flow in Female Healthy Volunteers and Diarrhea-predominant IBS Subjects
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 49
- 试验地点
- 1
- 主要终点
- Left Colon Mucosal Blood Flow (MBF)
研究概览
简要总结
This study will look at colonic mucosal blood flow in subjects who have taken alosetron vs placebo and healthy volunteers vs diarrhea-predominant Irritable Bowel Syndrome (d-IBS) patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •The subject signs and dates a written informed consent form prior to the initiation of any study-related activities.
- •The subject is between 18 and 49 years of age at the time of the Screening Visit.
- •The subject is female and either:
- •A healthy subject. Healthy subjects are defined as individuals who are free from clinically significant illness or disease as determined by their medical history (including family), physical examination, laboratory studies, and other tests.
- •A d-IBS patient per the Rome II criteria who has a normal result from a flexible sigmoidoscopy or colonoscopy, or flexible sigmoidoscopy plus barium enema, within 2 years of the Screening visit.
- •The subject demonstrates a negative urine pregnancy test result prior to investigational product administration and be either:
- •Of non-childbearing potential (i.e., physiologically incapable of becoming pregnant)
- •post-menopausal define as one year without menses in the absence of hormone replacement therapy.
- •sterilization (via hysterectomy or bilateral tubal ligation)
- •Of childbearing potential and agrees to one of the following acceptable non-hormonal contraceptive methods consistently and in accordance with both the product label and the instructions of a physician. Subjects will use effective contraceptive methods for at least one month prior to Screening and should continue to use the same contraceptive method throughout the study (Follow-up Visit).
- •Complete abstinence from intercourse
- •an intra-uterine device (IUD) inserted by a qualified physician, provided the IUD is not of the hormonal type and it has published data showing that the highest expected failure rate is less than 1% per year (not all IUDs meet this criterion)
- •double barrier method if comprised of a spermicide with either a condom or diaphragm
- •sterilization of partner The subject is ambulatory (defined as not depending exclusively on a wheelchair for mobility).
排除标准
- •The subject is taking oral contraceptive or other hormonal therapy.
- •The subject has a concurrent illness or disability that may affect the interpretation of clinical data, or otherwise contraindicates participation in this clinical study (e.g., an unstable cardiovascular, autoimmune, renal, hepatic, pulmonary, endocrine, metabolic, gastrointestinal, hematologic, or neurological condition).
- •The subject has constipation-predominant IBS (c-IBS) or alternating IBS per the ROME II criteria.
- •The subject has current evidence of or history of chronic or severe constipation, or a history of sequelae from constipation.
- •Evidence of a biochemical or structural abnormality of the digestive tract. These conditions include (but not limited to):
- •Current evidence, or history of (at any time in the past):
- •GI/Bowel conditions:
- •inflammatory bowel disease (Crohn's disease or ulcerative colitis)
- •celiac disease
- •laxative abuse (in the clinical judgement of the physician)
- •gastrointestinal surgery (exceptions include ≥6 months post-surgery appendectomy, cholecystectomy, fundoplication without gas bloat, or hiatal hernia repair; ≥3 months post-surgery herniorrhaphy without bowel resection)
- •gastroparesis
- •GI malignancy
- •carcinoid syndrome
- •amyloidosis
- •gastrointestinal adhesions
- •ischemic colitis
- •toxic megacolon
- •impaired intestinal circulation
- •gastrointestinal perforation
- •gastrointestinal obstruction and/or stricture
- •Ischemic cardiovascular conditions:
- •coronary artery disease (CAD)
- •significant atherosclerosis
- •chronic pancreatitis
- •thrombophlebitis or hypercoagulable state.
- •Current evidence of (within the past 6 months):
- •diverticulitis
- •symptomatic cholelithiasis
- •proctitis.
- •Current evidence of:
- •Hemoccult (+) stool.
- •The subject has a BMI of ≥
- •Mental impairment or inability or refusal to follow directions.
- •The subject has current evidence of, or has been treated for a malignancy within the past five years (other than localized basal cell, squamous cell skin cancer or cancer in situ that has been resected).
- •The subject exhibits evidence of hepatic dysfunction, viral hepatitis, or exhibits serum ALT (alanine aminotransferase) (SGPT), AST (aspartate aminotransferase) (SGOT) values >2.5 times the upper limit of normal or alkaline phosphatase or bilirubin values >2.0 times the upper limit of normal.
- •The subject displays renal impairment as evidenced by a serum creatinine value >2.0 mg/dl.
- •The subject has used any medication within the seven days prior to dosing, unless approved by the investigator and GlaxoSmithKline (GSK) personnel. Section 9.
- •The subject has used an investigational drug, or participated in an investigational study, within 30 days of the Screening Visit.
- •The subject has a history of drug allergies (including but not limited to hypersensitivity responses to alosetron which, in the opinion of the investigator, contraindicates the subject's participation in this study.
- •Subjects who have made a blood donation (>450mL) within 6 weeks prior to screening.
- •The subject has a history of alcohol and/or substance abuse within the past two years.
- •The subject is pregnant. The subject is breastfeeding.
结局指标
主要结局
Left Colon Mucosal Blood Flow (MBF)
时间窗: Day 6 after each treatment period
On Day 6 of each treatment period; 1 hour after dosing, subjects underwent a flexible sigmoidoscopy with Laser Doppler Flowmetry (LDF) to measure Mucosal Blood Flow (MBF). There were no pre-treatment LDF procedure, MBF was compared between the Healthy volunteers and D-irritable bowel syndrome (IBS) cohorts using the flow rates from the placebo treatment period.
次要结局
- Rectal Mucosal Blood Flow (MBF)(Day 6 after each treatment period)
- Left Colon and Rectal Mucosal Blood Flow Cohort Comparisons(Day 6 after each treatment period)
研究者
研究点 (1)
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