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临床试验/NCT04794153
NCT04794153
已完成
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Assessing the Muscle Protein Synthetic Response Following the Ingestion of a Variety of Protein Rich Whole Foods Compared to an Isolated Protein Source.

University of Exeter1 个研究点 分布在 1 个国家目标入组 66 人2021年5月1日

概览

阶段
不适用
干预措施
未指定
疾病 / 适应症
Nutritional Intervention Using Protein Rich Whole Food Sources
发起方
University of Exeter
入组人数
66
试验地点
1
主要终点
Postprandial Muscle protein Synthetic Response following the ingestion of a protein rich whole food source.
状态
已完成
最后更新
去年

概览

简要总结

Background To date, most of the literature investigating the role of dietary protein in muscle growth has focused on isolated protein sources. However, dietary protein is most commonly consumed within a whole food source. Consuming dietary protein within a whole food matrix may additionally stimulate muscle growth. The idea being, there may be other components within food, capable of producing a greater response.

Objectives: To assess the effect of consuming a variety of whole food sources, on the stimulation of muscle growth compared to an isolated protein source following a single bout of lower body resistance exercise.

Methods Young healthy resistance-trained volunteers will consume a protein rich whole food source, following a bout of lower body resistance exercise. Stable isotope IV infusions and repeated blood and muscle samples will be taken to assess protein digestion and absorption, as well as muscle protein synthesis rates.

Value of Research:

To determine whether whole food sources potentiate muscle protein synthesis rates (and to what extent across whole food sources) compared to an isolated protein source. In doing so, we can further investigate the nutrients involved that may be contributing to this effect.

注册库
clinicaltrials.gov
开始日期
2021年5月1日
结束日期
2024年5月1日
最后更新
去年
研究类型
Interventional
研究设计
Parallel
性别
All

研究者

责任方
Sponsor

入排标准

入选标准

  • Males and Females
  • BMI 18.5 - 30 kg/m2
  • Aged 18 - 40 years
  • Structured Resistance training consistently for \> 6 months
  • A 5-7 day "washout" period from any supplementation

排除标准

  • Age \>40 years
  • Body mass index (BMI) \<18.5 or \>30 kg/m2
  • Any metabolic impairments
  • Any cardiovascular impairments
  • High blood pressure (≥140/90 mmHg)
  • Any gastrointestinal disorders
  • Any medications known to affect protein and/or amino acid metabolism
  • A personal or family history of epilepsy, seizures or schizophrenia, motor disorder
  • Chronic over the counter use of pharmaceuticals (\> 1 month)
  • Allergic to any of the whole foods included in the study

结局指标

主要结局

Postprandial Muscle protein Synthetic Response following the ingestion of a protein rich whole food source.

时间窗: 2 years

84 participants will undergo a single bout of lower body exercise followed by the ingestion of one of the six protein rich whole food sources. Using stable isotope tracer methodology and muscle biopsy samples, the postprandial muscle protein synthetic response will be able to be calculated.

研究点 (1)

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