Impact of the Immunosuppressive Treatment, X-ray Exposition and Renal Pathology on Ovarian Reserve in Young Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 153
- 试验地点
- 1
- 主要终点
- Potential impact of X-ray exposition on ovarian reserve
研究概览
简要总结
Aging, renal pathology (eg SLE, ADPKD), X-ray exposition and pharmacological treatments, especially previous strong immunosuppression, may negatively influence the ovarian reserve in childbearing age women. Anti-Müllerian hormone (AMH) is regarded as biomarker for ovarian reserve.
Every female with renal disease regularly menstruating that met exclusion criteria could have participated. The aim was to assess ovarian reserve in female patients with normal menstrual cycle and kidney disease, including kidney transplant recipients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 44 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Conscious written approval
- •Autoimmunological disorder with kidneys affection/ kidney transplant recipient- Regular menstrual cycles
- •Age above 18 years old
排除标准
- •Irregular menstrual cycles
- •Menopause
- •Chemiotherapy or radiotherapy in the past
- •Surgical interventions within ovaries
- •Hypogonadotropic hypogonadism
- •Folliculoma
- •Age under 18 years old
结局指标
主要结局
Potential impact of X-ray exposition on ovarian reserve
时间窗: 1 day
Analysis of the impact of X-ray exposition \[mSv\] on AMH serum level \[ng/ml\]
To compare AMH levels between three groups
时间窗: 1 day
Serum AMH levels \[ng/ml\] measured using ELISA and compared between three groups
Potential impact of antiproliferative drugs on ovarian reserve
时间窗: 1 day
Analysis of the impact of antiproliferative drugs on AMH serum level \[ng/ml\]
Potential impact of underlying kidney disease on ovarian reserve
时间窗: 1 day
Analysis of the impact of underlying kidney disease (including SLE) on AMH serum level \[ng/ml\]
次要结局
未报告次要终点