A randomized phase 1b/2a trial of the effectiveness of intermittent hypoxia interventions in Parkinson*s disease
- Conditions
- Parkinson's disease10028037
- Registration Number
- NL-OMON53977
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
- Informed consent
- Clinical diagnosis of Parkinson*s disease by a movement disorder specialized
neurologist.
- Hoehn and Yahr staging 1 to and including 3 (indicating mild to moderate PD).
- Availability of an observant (partner, family member, friend, other relative)
during at-home hypoxic interventions.
- Individuals with diseases leading to restrictive and obstructive pulmonary
diseases, apnea and cardiac output deficits, such as pulmonary fibrosis, COPD,
sleep apnea or excessive alcoholic intake, and congestive heart failure
respectively, and individuals with coronary artery disease NYHA classes III and
IV
- Arterial blood gas abnormalities at screening procedure (as per normal limits
in chapter 8.1.1)
- Individuals with shortness of breath or other airway or breathing-related
inconvenience related to lack of dopaminergic medication
- Inability for in-clinic measurements in OFF phase
- Individuals with active deep brain stimulation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method