Genetic Association With Various Severities, Phenotypes and Endotypes of Asthma.
- Conditions
- Asthma
- Registration Number
- NCT06196034
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 2000
Inclusion Criteria:<br><br> - • All patients with confirmed diagnosis of asthma (defined as those with a<br> consistent history and prior documented evidence of variable airflow obstruction,<br> with evidence of an increase in FEV1 greater than 12% or 400 mL following<br> bronchodilator or bronchial hyperresponsiveness on bronchial provocation testing,<br> when stable) 12<br><br> - Able to sign written informed consent form to participate in the study.<br><br>Exclusion Criteria:<br><br> - • Patients currently with acute exacerbation of asthma by GINA guideline. (For<br> subjects with asthma exacerbation, they can join the study after 6 weeks post<br> recovery from the exacerbation.)<br><br> - Patients with respiratory diseases that can show similar symptoms to chronic<br> airway diseases such as bronchiectasis, tuberculosis(TB)-destroyed lung<br> parenchyma, endobronchial TB, and lung cancer, or those who have history of<br> these diseases based on physician's judgment.<br><br> - Patients currently diagnosed with pneumonia and acute bronchitis.<br><br>For control subject: the inclusion will be having no clinical diagnosis of asthma.
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method association between genetic polymorphisms and various severities of asthma
- Secondary Outcome Measures
Name Time Method Identify the most common genetic variants associated with asthma in Chinese patients.;Explore the frequency and distribution of these genetic variants in patients with various phenotypes and endotypes