Oral Health for Healthy Cognitive Aging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Change of occlusion units
研究概览
简要总结
Oral health is a critical factor of systemic health, although usually forgotten. A potential relation between cognitive deficits and oral diseases has been suggested. Adult cognitive dysfunctions have a high impact, not only economic, but social and in the family environment. Based on anatomical connectivity between the oral cavity and the central nervous system, the proposed study hypothesizes that masticatory function is a relevant determinant of human cognitive health. The restoration of canonical masticatory function and masticatory training could help to delay the development of such conditions. This project will also test if restoring phasic masticatory function improves the execution of cognitive tasks.
详细描述
Objective 1: To determine volumetric and anatomical changes of subcortical structures and cortical areas involved in the masticatory circuit and superior cognitive functions.
Objective 2: To determine the functional and brain connectivity changes associated with malocclusion and oral health.
Objective 3: To correlate the anatomic and functional changes associated with malocclusion and oral health with the performance of cognitive tasks representative of those executed in daily life.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For Dental occlusion restoration groups: Need of, at least, two molar teeth replacement in the same quadrant.
- •For Orthodontic treatment of malocclusion groups: Class I, II or III malocclusion.
排除标准
- •Psychoactive drug.
- •Central nervous system depressor.
- •Patients not willing or not able to consent.
研究组 & 干预措施
Intervention 2
Orthodontic treatment of malocclusion.
干预措施: Orthodontic treatment of malocclusion (Procedure)
Intervention 1
Dental occlusion restoration by placement of dental implants and prosthesis on missing teeth.
干预措施: Dental occlusion restoration (Procedure)
Wait list control 1
Group of patients that will be evaluated until they receive the dental occlusion restoration procedure.
干预措施: Dental occlusion restoration (Procedure)
Wait list control 2
Group of patients that will be evaluated until they receive the orthodontic treatment of malocclusion.
干预措施: Orthodontic treatment of malocclusion (Procedure)
结局指标
主要结局
Change of occlusion units
时间窗: Baseline, 6, 12 and 36 months
Number of teeth occluding with opposing teeth
Change of cerebral activity
时间窗: Baseline, 6, 12 and 36 months
Functional MRI
Change of cognitive function
时间窗: Baseline, 6, 12 and 36 months
Verbal fluency
Change of frame of mind
时间窗: Baseline, 6, 12 and 36 months
Beck test
Change of resting brain activity
时间窗: Baseline, 6, 12 and 36 months
Electroencephalographic activity
次要结局
未报告次要终点
研究者
Pablo Galindo-Moreno
Professor
Universidad de Granada