A Virtually Delivered Exercise Intervention To Mitigate Cognitive Deficits From Radiotherapy In AYAs With Brain Tumors
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Brain Tumor
- Sponsor
- M.D. Anderson Cancer Center
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- MD Anderson Symptom Inventory - Brain Tumor (MDASI - BT)
- Status
- Terminated
- Last Updated
- 9 months ago
Overview
Brief Summary
To test a new investigational virtual exercise program for adolescents and young adults (AYAs) with brain tumors who plan to receive cranial radiotherapy
Detailed Description
Primary Objective: Determine the feasibility and acceptability of a virtually supervised exercise intervention compared to control in AYAs with brain tumors undergoing cranial radiotherapy (CRT). Secondary Objective: Assess the effect of supervised exercise intervention on the neuroanatomic structure and cognitive function changes in AYAs with brain tumors undergoing CRT. Exploratory Objective: Assess the effect of supervised exercise intervention on other brain structure (white matter integrity), cognitive functions (attention, visual learning, psychomotor function, executive function, verbal learning, working memory and clinician-reported neurological exam outcomes), patient-reported health-related quality of life, objectively measured and patient-reported physical activity level, patient-reported dietary recall, objectively measured physical function assessments, and exercise progression (exercise volume). Assess the agreement between physical function tests performed twice virtually.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 15-39 years old
- •Self-reported diagnosis of a primary benign or malignant brain tumor or confirmed diagnosis of primary benign or malignant brain tumor radiographically or pathologically when available (relapse or newly diagnosed)
- •Plans to receive CRT at MDACC or, if the participant has already started CRT, the participant is eligible if they are within 3 weeks of the start of CRT
- •Received appropriate physician clearance
- •Able to move arms and legs, and ambulate safely
- •Participant is insufficiently active (reports less than 150 minutes of planned moderate-vigorous intensity activity per week in the prior week)
- •Participants and/or guardians are willing and able to provide informed consent
- •Has a smartphone with available space to download additional apps
- •Does not have sensorimotor strip impairment as indicated by the clinical team
- •Has internet access
Exclusion Criteria
- •Non-English speaking
- •Screen failure for exercise safety based on Physical Activity Readiness Questionnaire (PAR-Q).12
- •Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
- •Recent fracture or acute musculoskeletal injury that precludes ability to participate in supervised exercise training sessions
- •Cognitive and/or major sensory deficits that would impede the completion of research activities and assessments as deemed by the clinical team.
- •Self-reported diagnosis of a metastatic brain tumor or confirmed diagnosis of a metastatic brain tumor radiographically or pathologically when available
- •Self-report of pregnancy
- •Currently enrolled in another physical activity or exercise intervention
- •Self-reported pregnancy status
Outcomes
Primary Outcomes
MD Anderson Symptom Inventory - Brain Tumor (MDASI - BT)
Time Frame: Through study completion an average of 1 year.
Scale Score ranges from 0-10 0-Symptom has not been present 10-The symptom was as bad as you can imagine it could be