Age and Gender Corrected Body Mass Index

• Conditions: Esophageal Cancer

• Registration Number: NCT01958697
• Lead Sponsor: University Hospital, Gasthuisberg

Brief Summary

Esophagectomy for cancer is often accompanied with severe preoperative weight loss. Body Mass Index (BMI) values are age-independent and the same for both sexes. From the perspective that these two parameters should actually be taken into account too, we developed a model to calculate "age-gender specific BMI-percentiles" (AG-BMI) and tested this model in relation to survival outcome after esophagectomy for cancer.

Detailed Description

Age-Gender specific BMI percentiles are more accurate compared to the current BMI classes in predicting Overall Survival (OS) after esophagectomy for cancer. Furthermore we believe in a more devastating impact on OS from underweight and not from overweight.

By preoperatively identifying risk patients for poorer OS, especially the non-tumoral deaths, this can be a tool to tailor postoperative nutritional strategies to counter further weight loss and bringing postoperative weight to normal ranges.

Study Timeline

• Study Start: 2013-07
• Status Verified: 2013-10
• Primary Completion: 2013-10
• Study First Submitted: 2013-10-07
• Study First Submitted QC: 2013-10-07
• Last Update Submitted: 2013-10-07
• Study First Posted: 2013-10-09
• Last Update Posted: 2013-10-09
• Study Completion: 2014-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 650

Inclusion Criteria

• any type of esophagectomy

Exclusion Criteria

• Preoperative organ metastasis (cM+ or yM+)
• esophageal bypass surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall 5 year survival	5 years after esophagectomy	Overall 5-year survival after esophagectomy for cancer

Trial Locations

Locations (1)

Univresity Hospital Leuven - dept. Thoracic Surgery; 🇧🇪 Leuven, Belgium