Age and Gender Corrected Body Mass Index: When Preoperative Weight Loss and Underweight Are Becomming Clinically Significant in Esophagectomy for Cancer.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 650
- 试验地点
- 1
- 主要终点
- Overall 5 year survival
研究概览
简要总结
Esophagectomy for cancer is often accompanied with severe preoperative weight loss. Body Mass Index (BMI) values are age-independent and the same for both sexes. From the perspective that these two parameters should actually be taken into account too, we developed a model to calculate "age-gender specific BMI-percentiles" (AG-BMI) and tested this model in relation to survival outcome after esophagectomy for cancer.
详细描述
Age-Gender specific BMI percentiles are more accurate compared to the current BMI classes in predicting Overall Survival (OS) after esophagectomy for cancer. Furthermore we believe in a more devastating impact on OS from underweight and not from overweight.
By preoperatively identifying risk patients for poorer OS, especially the non-tumoral deaths, this can be a tool to tailor postoperative nutritional strategies to counter further weight loss and bringing postoperative weight to normal ranges.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •any type of esophagectomy
排除标准
- •Preoperative organ metastasis (cM+ or yM+)
- •esophageal bypass surgery
结局指标
主要结局
Overall 5 year survival
时间窗: 5 years after esophagectomy
Overall 5-year survival after esophagectomy for cancer
次要结局
未报告次要终点
研究者
Johnny Moons
Datamanager Thoracic Surgery
University Hospital, Gasthuisberg