Age and Gender Corrected Body Mass Index: When Preoperative Weight Loss and Underweight Are Becomming Clinically Significant in Esophagectomy for Cancer.
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 650
- Locations
- 1
- Primary Endpoint
- Overall 5 year survival
Study Overview
Brief Summary
Esophagectomy for cancer is often accompanied with severe preoperative weight loss. Body Mass Index (BMI) values are age-independent and the same for both sexes. From the perspective that these two parameters should actually be taken into account too, we developed a model to calculate "age-gender specific BMI-percentiles" (AG-BMI) and tested this model in relation to survival outcome after esophagectomy for cancer.
Detailed Description
Age-Gender specific BMI percentiles are more accurate compared to the current BMI classes in predicting Overall Survival (OS) after esophagectomy for cancer. Furthermore we believe in a more devastating impact on OS from underweight and not from overweight.
By preoperatively identifying risk patients for poorer OS, especially the non-tumoral deaths, this can be a tool to tailor postoperative nutritional strategies to counter further weight loss and bringing postoperative weight to normal ranges.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to 95 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •any type of esophagectomy
Exclusion Criteria
- •Preoperative organ metastasis (cM+ or yM+)
- •esophageal bypass surgery
Outcomes
Primary Outcomes
Overall 5 year survival
Time Frame: 5 years after esophagectomy
Overall 5-year survival after esophagectomy for cancer
Secondary Outcomes
No secondary outcomes reported
Investigators
Johnny Moons
Datamanager Thoracic Surgery
University Hospital, Gasthuisberg