ebulised heparin for lung injury

• Conditions: Patients with or at risk of developing Acute Respiratory Distress Syndrome.; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12612000418875
• Lead Sponsor: St.Vincents Hospital/Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-04-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 256

Inclusion Criteria

Receiving ventilation via an endotracheal tube
Started ventilation via an endotracheal tube yesterday or today
Expected to require invasive ventilation for at least all of today and all of tomorrow
PaO2 to FiO2 ratio less than 300
Active ventilator circuit humidification

Exclusion Criteria

Allergy to heparin; any history of heparin induced thrombocytopenia
Platelet count less than 50 x 109/L; activated partial thromboplastin time (APTT) is prolonged to greater than 80 seconds and this is not due to anticoagulant therapy
Uncontrolled bleeding; pulmonary bleeding during this hospital admission; any history of intracranial, spinal or epidural haemorrhage
Neurosurgical procedures during this hospital admission or such procedures are planned; an epidural catheter is in place
Hepatic encephalopathy or any history of gastrointestinal bleeding due to portal hypertension or biopsy proven cirrhosis with documented portal hypertension
Tracheostomy in place; usually receives home oxygen; usually receives any type of assisted ventilation at home e.g. continuous positive airway pressure for obstructive sleep apnoea
Cervical spinal cord injury associated with reduced long-term ability to breathe independently; spinal or peripheral nerve disease with a likely prolonged reduction in the ability to breathe independently e.g. Guillain-Barre syndrome, motor neurone disease
Receiving high frequency oscillation ventilation or extra corporeal membrane oxygenation
Pregnant or might be pregnant
Treatment limits restrict the provision of renal replacement therapy, inotropes, vasopressors or prolonged invasive ventilation; usually treated with haemodialysis or peritoneal dialysis for end-stage renal failure; dementia; death is deemed imminent or inevitable or there is underlying disease with a life expectancy of less than 90 days

Study & Design

• Study Type: Interventional
• Study Design: Not specified