Clinical and Biochemical Evaluation of Dental and Periodontal Conditions in Children With Juvenile Idiopathic Arthritis
- Conditions
- Decay, DentalJuvenile Idiopathic ArthritisGingivitis
- Interventions
- Diagnostic Test: Humans ELISA kits
- Registration Number
- NCT05217277
- Lead Sponsor
- Marmara University
- Brief Summary
Aimed to be done in the planned thesis to evaluate the dental and periodontal health of patients with newly diagnosed JIA and healthy-periodontal problems with cytokines from saliva and oxidative stress markers non-invasively, and thus, to determine the markers' evaluability in terms of markers in determining the state of inflammation among individuals with and without the disease.
- Detailed Description
Periodontal diseases and inflammatory diseases such as arthritis show similar clinical pathologies such as connective tissue deterioration and bone destruction. They carry the risk of being seen together and the possibility of mutual influence. It is important whether these patients have a difference in cytokine profile from individuals who do not have the disease. In the literature, it has been determined that pro and anti-inflammatory cytokines, which are involved in the pathogenesis of periodontitis, are also involved in the pathogenesis of juvenile idiopathic arthritis (JIA). Cytokines play an undeniable role in the pathogenesis of both diseases. The cytokine profile in periodontal disease is distinctly similar to that of rheumatoid arthritis (RA). As in RA, the level of pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) increase in periodontal disease. Again, it is stated that oxidative stress assessment is an important factor in evaluating the development of the disease. Saliva evaluation can be made with new oxidative stress markers that can be used in this sense.
On the subject of the proposed thesis; It is to determine the profile of dental and periodontal health in a specific group in terms of biochemical and microbiology using different body fluids together with clinical findings and has an interdisciplinary character. Aimed to be done in the planned thesis;
It was aimed to evaluate the dental and periodontal health of patients with newly diagnosed JIA and healthy-periodontal problems with cytokines from saliva and oxidative stress markers non-invasively, and thus, to determine the markers' evaluability in terms of markers in determining the state of inflammation among individuals with and without the disease.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 114
- healty patients
- used antibiotics within the last 3 months
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description healthy patient group with gingivitis Humans ELISA kits It is a group of healthy patients with gingivitis between the ages of 5-16 who have not taken antibiotics in the last 3 months. healthy patient group without gingivitis Humans ELISA kits It is a group of healthy patients without gingivitis between the ages of 5-16 who have not taken antibiotics in the last 3 months. patient with juvenile idiopathic arthritis and gingivitis Humans ELISA kits It is a group of patients between the ages of 5 and 16 who have recently been diagnosed with juvenile idiopathic arthritis and gingivitis, have not used medication yet. patient with juvenile idiopathic arthritis and without gingivitis Humans ELISA kits It is a group of patients between the ages of 5 and 16 who have recently been diagnosed with juvenile idiopathic arthritis and without gingivitis, have not used medication yet.
- Primary Outcome Measures
Name Time Method biochemical evaluation of saliva in juvenile idiopathic arthritis baseline Saliva samples were taken from the patients and the levels of interleukin-17, TNF alpha and Total antioxidant status in the saliva were measured with ELISA kits.
- Secondary Outcome Measures
Name Time Method Evaluation of periodontal health in patients with juvenile idiopathic arthritis baseline Silness-Loe plaque index (PI) was used to assess periodontal health.
Examination of periodontal health in patients with juvenile idiopathic arthritis baseline Gingival index (GI) was also used to examination periodontal health.
periodontal health in patients with juvenile idiopathic arthritis baseline Bleeding on prob index were used for periodontal health examination.
Evaluation of oral hygiene in patients with juvenile idiopathic arthritis baseline The number of caries in the patient was evaluated with the DMFT-dft index.
Trial Locations
- Locations (1)
Marmara University Faculty of Dentistry
🇹🇷Istanbul, Maltepe, Turkey