Angiogenesis Markers in Primiparas Versus Multiparas: Relevance to Preeclampsia Incidence

• Conditions: Pre-Eclampsia

• Registration Number: NCT00262093
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

The reason for having a higher incidence of preeclampsia in primiparas may involve angiogenesis imbalance in these patients.

Detailed Description

Primiparity is one of the main risk factors for having preeclampsia during pregnancy. Recently, sFlt-1, soluble FMS-like tyrosine kinase-1, has been shown to be a major molecule involved in the pathogenesis of preeclampsia. Higher sFlt-1 mRNA, higher serum levels of sFlt-1 as well as lower PlGF, placental growth factor, have been found in preeclamptic patients.

We intend to check the angiogenesis profile of primiparas as compared to multiparas.

Study Timeline

• Status Verified: 2005-11
• Study Start: 2005-11
• Study First Submitted: 2005-12-04
• Study First Submitted QC: 2005-12-04
• Study First Posted: 2005-12-06
• Last Update Submitted: 2007-03-19
• Last Update Posted: 2007-03-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

• Every delivery

Exclusion Criteria

• Preeclampsia or pregnancy induced hypertension

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Hadassah Medical Organization; 🇮🇱 Jerusalem, Israel