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临床试验/CTRI/2025/10/095617
CTRI/2025/10/095617尚未招募2 期

Comparison of postoperative inflammation with or without preoperative high dose dexamethasone after emergency laparotomy: A randomised controlled study

Maulana Azad Medical College and associated hospitals1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年10月18日最近更新:

试验速览

阶段
2 期
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
Change in CRP levels

研究概览

简要总结

All patients presenting in Surgery emergency with diagnosis of intestinal obstruction or viscus perforation will be included in the study and randomized into 2 groups-

Group A: high dose dexamethasone administration, Group B: without dexamethasone administration

The levels of CRP and IL6 will be recorded in preoperative and postoperative period and compared in both groups.

Patients of both the groups will be evaluated for Systemic inflammatory response syndrome, surgical site infection, duration of hospital stay and compared.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant Blinded

入排标准

年龄范围
18.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Patients presenting to surgery emergency with acute abdomen.

排除标准

  • Patients with diabetes mellitus People living with HIV Patients with chronic steroid usage Patients with chronic kidney disease Patients with chronic liver disease Patients with disseminated malignancy.

结局指标

主要结局

Change in CRP levels

时间窗: before and 24 hours after surgery

次要结局

  • Change in IL6 levels(before and 24 hours after surgery)
  • Percentage of patients developing systemic inflammatory response syndrome(Till post-operative day 7)
  • Percentage of patients developing surgical site infections(Till post-operative day 30)
  • Duration of hospital stay in days(Till the time of discharge)

研究者

发起方
Maulana Azad Medical College and associated hospitals
申办方类型
Government medical college
责任方
Principal Investigator
主要研究者

Dr Nancy Rustagi

Maulana Azad Medical College and associated hospitals

研究点 (1)

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