Target attainment of ciprofloxacin in patients admitted to a general ward: a prospective observational study.
Completed
- Conditions
- nvt1000401810038430
- Registration Number
- NL-OMON44298
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Receiving ciprofloxacin therapy as part of standard care for a (suspected) bacterial infection; urinary tract infection, pneumonia, wound infection, sepsis, abdominal infection or other infection.
Age * 18 years and admitted to a general ward of the AMC.
Exclusion Criteria
Incapacitated patients.
Treatment with ciprofloxacin is started elsewhere.
Hemodialysis or peritoneal dialysis during treatment with ciprofloxacin.
Ciprofloxacin given as prophylactic treatment and not as a treatment of a (suspected) infection.
Patients admitted to the intensive care unit (ICU).
Severely burned patients, defined as a burned surface *10%.
Persons who cannot speak and read the English or Dutch language.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>AUC0-24/MIC </p><br>
- Secondary Outcome Measures
Name Time Method <p>Cmax/MIC<br /><br>fAUC0-24/MIC<br /><br>Clinical response: days of fever, decrease (%) in CRP and leucocyte count,<br /><br>length of hospital stay and need for switching ciprofloxacin to a more<br /><br>broad-spectrum antibiotic. </p><br>