Effect of Caloric Restriction and Gastric Bypass on Resting Metabolic Rate

Not Applicable

Terminated

• Conditions: Obesity
• Interventions: Procedure: Gastric bypass; Behavioral: Caloric restriction

• Registration Number: NCT01595945
• Lead Sponsor: KiloCoach e.U.

Brief Summary

Studies in overweight and obese subjects show a decline in resting metabolic rate (RMR) even after moderate caloric restriction. Yet the onset and course of such a metabolic adaption is still unclear. Lower resting metabolic rates were also reported after gastric banding bariatric surgery but have not yet been investigated in subjects after gastric bypass. The purpose of this study is to investigate the consequences on resting metabolic rate in subjects with obesity after moderate caloric restriction or gastric bypass.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-04
• Study First Submitted: 2012-05-09
• Study First Submitted QC: 2012-05-09
• Study First Posted: 2012-05-10
• Status Verified: 2015-02
• Primary Completion: 2015-02
• Study Completion: 2015-02
• Last Update Submitted: 2015-02-04
• Last Update Posted: 2015-02-05

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• BMI ≥30 kg/m2

Exclusion Criteria

• Marked weight reduction in the last 2 years (>5% of initial body weight)
• Recent extreme fasting (during the last month)
• Manifest eating disorders (assignment to a specialist for eating disorders)
• Severe psychiatric disorders requiring treatment
• Pregnancy, lactation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Gastric bypass	Gastric bypass	Subjects with planned gastric bypass surgery are followed-up in regard of resting metabolic rate.
Caloric restriction	Caloric restriction	Caloric restriction calculated by an online weight management program (based on subject's starting weight, start BMI, age, target weight and time span). Subjects are followed-up in regard to resting metabolic rate.

Primary Outcome Measures

Name	Time	Method
Resting metabolic rate	24 weeks

Secondary Outcome Measures

Name	Time	Method
Body Mass Index	24 weeks
Body composition (muscle mass, fat mass)	24 weeks
Caloric restriction	24 weeks
Weight loss	24 weeks

Trial Locations

Locations (2)

Hospital Barmherzige Schwestern Vienna; 🇦🇹 Vienna, Austria

KiloCoach e.U.; 🇦🇹 Vienna, Austria