Transcranial Direct Current Stimulation (tDCS) in the treatment of cognitive deficit in schizophrenia

ational Institute of Mental Health0 sites30 target enrollmentAugust 18, 2021

Overview

No summary available.

Registry

who.int

Start Date

August 18, 2021

End Date

December 31, 2024

Last Updated

2 years ago

Study Type

Interventional

Sex

All

Sponsor

ational Institute of Mental Health

•1\. Male and female inpatients or outpatients aged 18\-50 years
•2\. Meet ICD\-10 criteria for schizophrenia (F20\)
•3\. The mental ability to understand and sign the Informed Consent Form
•4\. Being on a stable and adequate dose of antipsychotics (monotherapy or combination) for at least two weeks before enrollment and if clinically appropriate to continue on an unchanged dose of antipsychotics during the trial
•5\. The score for mildly to moderately ill patients in the Positive and Negative Syndrome Scale (PANSS \</\= 75\) at the initial visit

•1\. Psychiatric comorbidity on axis I and II according to DSM V in the 6 months before enrollment to the study
•2\. Contraindications of tDCS (skin disease, superficial injury and fracture or infraction of skull in the stimulation area, epilepsy, metallic plates in the head)
•3\. Inadequate treatment of psychosis according to recommended guidelines (duration, dose)
•4\. Pregnancy or breastfeeding
•5\. Patients with severe and/or unstable somatic disorders (cardiovascular, disease, neoplasms, endocrinology disorders etc)
•6\. Patients treated with electroconvulsive therapy less than 3 months before enrollment or suffering from neurological disorder (e.g. epilepsy, head trauma with loss of consciousness)
•7\. Substantial suicidal risk as judged by the treating psychiatrist
•8\. History of substance\-induced disorders in the last year except for nicotine dependency
•9\. Sensory and motor impairment precluding the participation in CT