Systematic Review and Meta-analysis of Cereal or Grain Consumption and Gastric Cancer

Completed

• Conditions: Gastric Cancer
• Interventions: Dietary Supplement: cereal or grain consumption

• Registration Number: NCT03419663
• Lead Sponsor: West China Hospital

Brief Summary

This project involved a systematic literature review of published trials of cereal or grain in relation to the risk of gastric cancer. Data was extracted from the publications on PubMed, EMBASE, Cochrane Library.A traditional meta-analysis, subgroup analysis, and heterogeneity was conducted on the extracted data.

Detailed Description

Investigators searched PubMed, EMBASE, Cochrane Library for studies focusing on cereal or grain in relation to the risk of gastric cancer up to October 2017. Summary odd ratios (OR) and 95% confidence intervals (CI) were calculated by using either random effect models or fixed effect models according to the heterogeneity of included studies. Subgroup analysis, heterogeneity, and publication bias were also performed.

Study Timeline

• Study Start: 2017-09-12
• Primary Completion: 2017-12-20
• Study Completion: 2018-01-10
• Study First Submitted: 2018-01-19
• Study First Submitted QC: 2018-01-26
• Status Verified: 2018-02
• Last Update Submitted: 2018-02-01
• Study First Posted: 2018-02-05
• Last Update Posted: 2018-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• a case-control studies or a cohort study
• investigate the association between cereal or grain intake and GC occurrence
• report an odds ratio (OR) or relative risk (RR) with corresponding 95% confidence intervals (CI)
• provide sufficient data to estimate OR or RR

Exclusion Criteria

• Non-human studies
• GC mortality-based cohort studies

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
gastric cancer	cereal or grain consumption	-

Primary Outcome Measures

Name	Time	Method
the relationship between overall cereal consumption and gastric cancer occurance	up to 2 years	perform a pooled analysis of included studies with OR through STATA 12.0

Secondary Outcome Measures

Name	Time	Method
the relationship between whole grain and gastric cancer occurance	up to 2 years	perform a subgroup analysis to summarize the related OR through STATA 12.0
the relationship between other grain and gastric cancer occurance	up to 2 years	perform a subgroup analysis to summarize the related OR through STATA 12.0
the relationship between refined grain and gastric cancer occurance	up to 2 years	perform a subgroup analysis to summarize the related OR through STATA 12.0

Trial Locations

Locations (1)

West China Hospital, Sichuan University; 🇨🇳 Chengdu, Sichuan, China