Evaluation of UDP-glucose as a Urinary Biomarker for Early Detection of Cardiac Surgery-associated Pediatric Acute Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 250
- 试验地点
- 2
- 主要终点
- AKI
研究概览
简要总结
Acute kidney injury (AKI) is common in children after cardiac surgery with a reported incidence of 20-40%. Pediatric AKI has been found to be associated with important short and long-term adverse outcomes.
A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies exclusively on elevation of serum creatinine concentration and oliguria. Both of these markers lack sensitivity and specificity, and result in delayed detection of kidney injury.
This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary bypass.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 8 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •less than or equal to 8 years of age
- •scheduled for cardiac surgery
排除标准
- •severe pre-existing renal insufficiency
研究组 & 干预措施
AKI Group
Patients developing AKI after surgery
干预措施: Discarded urine sample (Other)
No AKI Group
Patients who do not develop AKI after surgery
干预措施: Discarded urine sample (Other)
结局指标
主要结局
AKI
时间窗: within 72 hours after surgery
development of AKI
次要结局
未报告次要终点
研究者
Douglas Atkinson
Cardiac Anesthesiologist
Boston Children's Hospital