Evaluation of UDP-glucose as a Urinary Biomarker for Early Detection of Cardiac Surgery-associated Pediatric Acute Kidney Injury
- Conditions
- Acute Kidney Injury
- Interventions
- Other: Discarded urine sample
- Registration Number
- NCT03263325
- Lead Sponsor
- Boston Children's Hospital
- Brief Summary
Acute kidney injury (AKI) is common in children after cardiac surgery with a reported incidence of 20-40%. Pediatric AKI has been found to be associated with important short and long-term adverse outcomes.
A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies exclusively on elevation of serum creatinine concentration and oliguria. Both of these markers lack sensitivity and specificity, and result in delayed detection of kidney injury.
This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary bypass.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 250
- less than or equal to 8 years of age
- scheduled for cardiac surgery
- severe pre-existing renal insufficiency
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description AKI Group Discarded urine sample Patients developing AKI after surgery No AKI Group Discarded urine sample Patients who do not develop AKI after surgery
- Primary Outcome Measures
Name Time Method AKI within 72 hours after surgery development of AKI
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Boston Children's Hospital
🇺🇸Boston, Massachusetts, United States