Value of Radionuclide Cisternography

Completed

• Conditions: CSF Leak; Fistula

• Registration Number: NCT02876614
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Radionuclide cisternography (RC) is a nuclear medicine examination based on intrathecal injection of \[111In\]diethylenetriaminepentaacetic acid (\[111In\]DTPA). It is prescribed for two recommendations: detection of cerebrospinal fluid (CSF) leak/fistula and diagnosis of normal pressure hydrocephalus.

In the search part of CSF leak/fistula, RC offers the benefit of a 24-hour study of CSF unlike other reference tests.

In addition to SPECT/CT imaging, the radiopharmacist performs sampling in nasal cavities and throat of the patient to collect a possible flow of CSF.

These samples are analysed by radioactivity measurements and bring an added value to the exam.

The interest of this examination for management of CSF leak/fistula remains unclear.

The aim of this study is to identify and analyse results of all RC examinations performed since 2005 in the Nuclear Medicine department of the Neurological Hospital.

The full analysis of patients will allow discussing the role of RC in management of CSF leak/fistulae in clinical practice.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-01
• Primary Completion: 2005-12
• Study Completion: 2005-12
• Status Verified: 2016-08
• Study First Submitted: 2016-08-09
• Study First Submitted QC: 2016-08-18
• Last Update Submitted: 2016-08-18
• Study First Posted: 2016-08-24
• Last Update Posted: 2016-08-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 113

Inclusion Criteria

• patients who received a convocation for realization of RC (extraction with GERA, software of Nuclear Medicine)

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Exclusion Criteria

• patients who received a convocation for realization of RC with "valve" protocol

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
RC /SPECT/CT imaging	one week	Results of RC including results of SPECT/CT imaging and results of swabs counting (nasal cavities and throat or ear if applicable)